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Literature summary extracted from

  • Konings, J.; Hoving, L.R.; Ariens, R.S.; Hethershaw, E.L.; Ninivaggi, M.; Hardy, L.J.; de Laat, B.; Ten Cate, H.; Philippou, H.; Govers-Riemslag, J.W.
    The role of activated coagulation factor XII in overall clot stability and fibrinolysis (2015), Thromb. Res., 136, 474-480 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.38 factor XI + H2O Homo sapiens
-
 factor XIa + ?
-
 ?
3.4.21.38 plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.38 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.38 factor XI + H2O
-
 Homo sapiens factor XIa + ?
-
 ?
3.4.21.38 plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?
3.4.21.38 S-2251 + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.38 ? x * 80000, calculated from amino acid sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.38 activated coagulation factor XII
-
 Homo sapiens
3.4.21.38 alpha-FXIIa
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.38 physiological function the enzyme enhances fibrinolysis in the presence of plasminogen. The enzyme first strengthens the clot structure during clot formation and thereafter contributes towards fibrinolysis Homo sapiens